Povidone-Iodine for Nasal Decolonization

Completed · Phase 4 · Has a placebo group

Conditions studied: Surgical Wound Infection, Preoperative Care, Methicillin-Resistant Staphylococcus Aureus

In brief

To evaluate the efficacy and tolerability of 10% povidone-iodine in eliminating nasal carriage of Staphylococcus aureus and MRSA. To determine whether a more convenient, single-dose, pre-operative 10% povidone-iodine (PI) application is effective in reducing nasal carriage of S. aureus and MRSA. We expect a statistically significant decrease in S. aureus/MRSA colonization in nasal cultures taken perioperatively after intervention in patients who received pretreatment with PI as compared to patients who received normal saline (NS).

Key facts

Study ID

NCT05529173

Run by

Rutgers, The State University of New Jersey

People needed

192

Starts

2022-09-06

Expected to finish

2023-11-17

Last updated by the study team

2024-11-13

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• community-based patients ages 18-80
• American Society of Anesthesiology (ASA) 1-3
• undergoing an outpatient surgery for at least 1 hour and up to 6 hours duration

You may not qualify if…

• pregnancy
• allergy to povidone-iodine
• infectious indication for surgery or preexisting known infection/wound
• immunocompromised state
• use of chemotherapy or steroids within 30 days prior to surgery
• use of antimicrobial therapy within 30 days prior to surgery
• surgeries where field avoidance prevents intraoperative access to the nares

Where it is running

• University Hospital — Newark, New Jersey, United States

Full record on ClinicalTrials.gov

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