Personalized Postoperative Pain Management Following Thoracic Surgery in Adults

Recruiting now

Conditions studied: Thoracic Surgery, Pneumonectomy, Lobectomy, Segmentectomy

In brief

The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research. This research focuses on two of the most commonly used oral opioid analgesics, oxycodone, and methadone, in adults following thoracic surgery. Major inpatient thoracic surgeries (TS) for lung disease are common and extremely painful surgeries and are associated with sever post-surgical pain, high incidence of chronic post-surgical pain (CPSP), excess opioid use, costly immediate postoperative opioid adverse events (AEs), and long hospital stays. This study is aiming to develop proactive risk prediction algorithms for precision surgical pain relief in adult TS patients through comparison of actual clinical outcomes with standard of care to predicted outcomes based on personalized risk assessments.

Key facts

Study ID

NCT05525923

Run by

OpalGenix, Inc

People needed

200

Starts

2023-11-30

Expected to finish

2028-03-01

Last updated by the study team

2025-05-01

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• >18 years
• American Society of Anesthesiologists (ASA) Physical Status 1, 2, 3
• Undergoing thoracic surgery (TS; pneumonectomy, lobectomy and segmentectomy)

You may not qualify if…

• Children (<18 years)
• Pregnant women
• American Society of Anesthesiologists (ASA) Physical Status 4 or above
• Non-English speaking
• Outpatient surgery
• Concomitant additional surgical procedures
• Significant liver and kidney dysfunction
• Significant cardiorespiratory compromise
• Patients with polysubstance use (e.g., cocaine, marijuana, amphetamine, etc.)

Where it is running

• UPMC Presbyterian Hospital — Pittsburgh, Pennsylvania, United States (enrolling)
• UPMC Mercy Hospital — Pittsburgh, Pennsylvania, United States (enrolling)
• UPMC Shadyside Hospital — Pittsburgh, Pennsylvania, United States (enrolling)
• UPMC Passavant Hospital — Pittsburgh, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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