Delayed Immunological Tolerance in Patients With Well-functioning Pre-existing HLA-matched Kidney Transplants
Recruiting now · Phase 1
Conditions studied: End Stage Kidney Disease, Immunological Tolerance, Kidney Transplant Failure and Rejection, Chronic Kidney Diseases
In brief
The study seeks to determine if patients with a pre-existing, well-functioning kidney transplant from a HLA-identical living donor can be withdrawn from immunosuppressive medications without compromising allograft function through hematopoietic stem cell (HPSC) infusion from the same donor. HPSC infusion will be preceded by a conditioning regimen of total lymphoid irradiation (TLI) and rabbit anti-thymocyte globulin (rATG).
Key facts
- Study ID
- NCT05525507
- Run by
- University of California, Los Angeles
- People needed
- 10
- Starts
- 2022-12-21
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2025-11-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
Where it is running
- UCLA — Los Angeles, California, United States (enrolling)
Full record on ClinicalTrials.gov
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