RCT of Combination Effect of Vibration Treatment and HMB Supplementation on Myosteatosis and NMJ Degeneration
Recruiting now · Not applicable
Conditions studied: Sarcopenia, Connective Tissue Diseases in Old Age, Musculoskeletal Abnormalities
In brief
The investigators' pre-clinical study confirms the positive effects of combined treatment (VT + HMB) on reducing fat-to-lean tissue ratio, intramuscular fat infiltration and increasing muscle strength in sarcopenia animal model. The results showed that fat mass could be decreased by \~32%, while histology Oil Red O staining indicated a decrease of fat by almost 60%; in contrast, lean muscle mass increased by \~14%. On muscle strength, combined treatment increased twitch force, tetanic force and grip strength by \~30-66%. These in vivo results are very encouraging and the investigators should explore its potential in clinical translation. As VT and HMB supplement have been commercially available and their compliance rates are satisfactory, they can be translated to clinical application easily. The investigators' next step is to confirm its clinical efficacy, so that sarcopenia becomes a new indication of VT and HMB. The hypothesis is that combined treatment of VT and HMB can retard the progression of sarcopenia in human, in terms of muscle mass, muscle strength and performance.
Key facts
- Study ID
- NCT05525039
- Run by
- Chinese University of Hong Kong
- People needed
- 200
- Starts
- 2023-01-12
- Expected to finish
- 2025-09-01
- Last updated by the study team
- 2025-02-13
Who can join
Age: 60 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects aged 60 years or above
- Subjects failed in AWGS algorithm
- skeletal muscle mass by BIA (male at <7.0 kg/m\^2, female at <5.7 kg/m\^2), and
- handgrip strength (male at <28 kg, female at <18kg), and/or
- gait speed test (>1m/s)
You may not qualify if…
- Subjects with pathological bone diseases
- Subjects with chronic inflammatory condition (e.g. rheumatoid arthritis)
- Subjects with neurological problems
- Subjects receiving regular exercise
- Subjecs who are chair-/bed- bound
- Subjects with malignancy
- Subjects with cardiovascular concern such as with pace-maker in-situ
- Subjects with acute fractures or severe osteoarthritis
Where it is running
- The Chinese University of Hong Kong Jockey Club Centre for Osteoporosis Care and Control — Hong Kong, Hong Kong (enrolling)
- The Chinese University of Hong Kong, Department of Orthopaedics and Traumatology, 1/F Li Ka Shing Outpatient Clinic (North), PWH — Hong Kong, Hong Kong (enrolling)
- Evangelical Luthera Church Social Service - Hong Kong — Hong Kong, Hong Kong
Full record on ClinicalTrials.gov
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