A Study of Brepocitinib in Adults With Active Non-Infectious Non-Anterior Uveitis

Completed · Phase 2

Conditions studied: Non-infectious Intermediate Uveitis, Non-infectious Posterior Uveitis, Non-infectious Pan Uveitis

In brief

This study will evaluate the clinical safety and efficacy of oral brepocitinib in participants with active intermediate, posterior, or pan non-infectious uveitis (NIU).

Key facts

Study ID

NCT05523765

Run by

Priovant Therapeutics, Inc.

People needed

26

Starts

2022-11-14

Expected to finish

2024-07-30

Last updated by the study team

2025-07-25

Who can join

Age: 18 and older, up to 74. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult subjects (18-74 years old)
• Diagnosis of non-infectious uveitis (intermediate uveitis, posterior uveitis, or panuveitis).
• Active uveitic disease as defined by the presence of at least 1 of the following parameters in at least 1 eye, as determined by the investigator:
• Active, inflammatory chorioretinal and/or retinal vascular lesion; OR
• ≥2+ vitreous haze grade (NEI/SUN criteria).
• Receiving up to one non-corticosteroid, non-biologic, immunomodulatory therapy
• Weight > 40 kg with a body mass index < 40 kg/m2.

You may not qualify if…

• Has isolated anterior uveitis.
• Has confirmed or suspected current diagnosis of infectious uveitis
• History of:
• Any lymphoproliferative disorder
• Active malignancy;
• History of cancer within 5 years prior to screening (exceptions for basal cell carcinoma, squamous cell carcinoma, ductal carcinoma in situ of the breast, carcinoma in situ of the uterine cervix, or thyroid carcinoma.)
• At risk of thrombosis and cardiovascular disease
• Have a high risk for herpes zoster reactivation
• Have active or recent infections
• Other protocol defined Inclusion/Exclusion criteria may apply

Where it is running

• Clinical Trial Site — Los Angeles, California, United States
• Clinical Trial Site — Palo Alto, California, United States
• Clinical Trial Site — Pasadena, California, United States
• Clinical Trial Site — Lakewood, Colorado, United States
• Clinical Trial Site — Waltham, Massachusetts, United States
• Clinical Trial Site — St Louis, Missouri, United States
• Clinical Trial Site — Palisades Park, New Jersey, United States
• Clinical Trial Site — Durham, North Carolina, United States
• Clinical Trial Site — Winston-Salem, North Carolina, United States
• Clinical Trial Site — Eugene, Oregon, United States
• Clinical Trial Site — Nashville, Tennessee, United States
• Clinical Trial Site — Bellaire, Texas, United States
• Clinical Trial Site — Katy, Texas, United States
• Clinical Trial Site — Plano, Texas, United States
• Clinical Trial Site — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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