The Registry Study of Genetic Alterations of Oropharyngeal Cancer in Taiwan
Recruiting now
Conditions studied: Oropharyngeal Squamous Cell Carcinoma
In brief
We will use the next-generation sequencing (NGS) technology to identify genomic alterations of Taiwanese HPV positive and negative oropharyngeal squamous cell carcinoma (OPSCC) for novel biomarker development and the study design of potential clinical trials or translational research.
Key facts
- Study ID
- NCT05522881
- Run by
- National Health Research Institutes, Taiwan
- People needed
- 410
- Starts
- 2022-11-25
- Expected to finish
- 2029-12-01
- Last updated by the study team
- 2026-07-02
Who can join
Age: 20 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Ages 20 and above
- Pathological reported as squamous cell carcinoma of head and neck
- Available p16 immunohistochemical staining status (restricted to the OPSCC subgroup)
- Participants have both archival tumor tissues from the primary head and neck SCC and from the first recurrent tumor (for the recurrence subgroup)
- Recurrence status is defined as the reappearance of the disease occurring more than 6 months following curative surgery and/or chemoradiotherapy in the recurrence subgroup
- Willingness to provide archival or newly obtained tumor tissues for current study proposal
- Life expectancy more than 3 months
- Patients fully understand the protocol with the willingness to have regular follow-up
You may not qualify if…
- Inability to cooperate by providing a complete medical history
- No available tumor tissues for genetic testing
- Undesirable compliance
- Having a known additional malignancy that is progressing or has required active treatment within the past 3 years. Participants with basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ (e.g., cervical carcinoma in situ) that have undergone potentially curative therapy are not excluded
Where it is running
- Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Taiwan (enrolling)
- Kaohsiung Veterans General Hospital — Kaohsiung City, Taiwan (enrolling)
- China Medical University Hospital — Taichung, Taiwan (enrolling)
- Taichung Veterans General Hospital — Taichung, Taiwan (enrolling)
- National Cheng Kung University Hospital — Tainan, Taiwan (enrolling)
- Pei-Jen Alex Lou — Taipei, Taiwan (enrolling)
- Taipei Veterans General Hospital — Taipei, Taiwan (enrolling)
Full record on ClinicalTrials.gov
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