Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome

Enrolling by invitation · Not applicable

Conditions studied: Tibial Shaft Fracture, Tibial Plateau Fracture

In brief

The purpose of this study is to evaluate both genotypic differences and differences in local gene expression in individuals who develop acute traumatic compartment syndrome relative to control patients with at-risk lower extremity fractures who do not develop compartment syndrome.

Key facts

Study ID

NCT05521958

Run by

University of Utah

People needed

80

Starts

2022-06-10

Expected to finish

2028-06-01

Last updated by the study team

2026-04-29

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient 18+ years of age. English speaking.
• Patients with the clinical diagnosis of lower leg acute compartment syndrome secondary to tibial shaft or tibial plateau fracture.
• Patients without clinical compartment syndrome undergoing operative intervention within 48 hours of injury for tibial shaft or tibial plateau fractures.
• Patients with the clinical diagnosis of exertional compartment syndrome with planned surgical intervention.

You may not qualify if…

• Non-english speaking participants

Where it is running

• University of Utah Orthopaedic Center — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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