A Study of RGLS8429 in Patients With Autosomal Dominant Polycystic Kidney Disease
Completed · Phase 1 · Has a placebo group
Conditions studied: Autosomal Dominant Polycystic Kidney Disease, ADPKD, Polycystic Kidney, Autosomal Dominant
In brief
Primary Objectives * To assess the safety and tolerability of RGLS8429 * To assess the impact of RGLS8429 on ADPKD biomarkers Secondary Objectives * To assess the impact of RGLS8429 on height-adjusted total kidney volume (htTKV) * To characterize the pharmacokinetic (PK) properties of RGLS8429 * To assess the impact of RGLS8429 on renal function
Key facts
- Study ID
- NCT05521191
- Run by
- Regulus Therapeutics Inc.
- People needed
- 68
- Starts
- 2022-10-06
- Expected to finish
- 2025-03-27
- Last updated by the study team
- 2025-06-03
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Centricity Research Phoenix Multispecialty — Mesa, Arizona, United States
- Academic Medical Research Institute — Los Angeles, California, United States
- Yale Nephrology Outpatient Clinic — New Haven, Connecticut, United States
- Mayo Clinic - Florida — Jacksonville, Florida, United States
- Elixia — Orlando, Florida, United States
- Southeastern Clinical Research Institute, LLC — Augusta, Georgia, United States
- CARE Institute — Boise, Idaho, United States
- CARE Institute — Chubbuck, Idaho, United States
- The Idaho Kidney Institute — Idaho Falls, Idaho, United States
- University of Chicago — Chicago, Illinois, United States
- Research by Design, LLC — Chicago, Illinois, United States
- University of Iowa — Iowa City, Iowa, United States
- University of Kansas Medical Center Jared Grantham Kidney Institute — Kansas City, Kansas, United States
- Witchita Nephrology Group, PA — Wichita, Kansas, United States
- University of Maryland School of Medicine, Nephrology — Baltimore, Maryland, United States
- Tufts Medical Center — Boston, Massachusetts, United States
- St. Clair Nephrology Research — Roseville, Michigan, United States
- Mayo Clinic - Rochester — Rochester, Minnesota, United States
- Northeast Clinical Research Center — Bethlehem, Pennsylvania, United States
- University of Texas Southwestern Medical Center — Dallas, Texas, United States
- Swedish Center for Comprehensive Care — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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