Overcoming Nicotine Dependence to Enable Quitting
Recruiting now · Phase 1/Phase 2
Conditions studied: Tobacco Use, Smoking Cessation, Smoking Behaviors, Nicotine Dependence, Nicotine Withdrawal
In brief
Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are willing to set a quit date. This is problematic because few smokers are ready to set a quit date at any given time, and a smoker's stated intention to quit can change rapidly. One novel potential treatment strategy is to foster practice quitting (PQ), defined as attempting to not smoke for a few hours or days, without pressure or expectation to permanently quit. Although a growing body of evidence supports the role of practice quitting in fostering permanent quit attempts and cessation, there is a significant knowledge gap regarding which treatment strategies should be used to engage smokers in practice quitting. The proposed study will test the role of PQ counseling vs. Motivational Interviewing (MI) counseling, and NRT sampling (four-week supply of nicotine lozenges and patches) vs. none.
Key facts
- Study ID
- NCT05513872
- Run by
- Rush University Medical Center
- People needed
- 780
- Starts
- 2023-03-24
- Expected to finish
- 2027-08-30
- Last updated by the study team
- 2025-08-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Eligible participants will be males and females who:
- are 18 years or older
- report current daily cigarette smoking (≥ 5 cigarettes per day)
- are not planning to quit in the next 30 days
- are not currently engaged in smoking cessation treatment
- are motivated to quit or engage in a non-cessation goal (i.e., reduce smoking, learn more about treatment options, and/ or try out skills to change smoking) in the next 6 months
- are English speaking
- reside in the continental United States
- have access to a smartphone that can be used to complete study procedures
You may not qualify if…
- Participants will be excluded for daily vaping/ electronic cigarettes use (i.e., use for ≥ 25 days within past 30 days) and any FDA contraindications for NRT use if they:
- are pregnant/breastfeeding
- had recent cardiovascular trauma such as myocardial infarction
- had a stroke within the past 3 months
Where it is running
- Rush University Medical Center — Chicago, Illinois, United States (enrolling)
Full record on ClinicalTrials.gov
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