Investigational Imaging Technique During Brain Surgery
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Conditions studied: Astrocytoma, Glioblastoma, Oligodendroglioma
In brief
This early phase I trial tests the safety and reliability of an investigational imaging technique called quantitative oblique back illumination microscopy (qOBM) during brain surgery for detecting brain tumors and brain tumor margins in patients with glioblastoma, astrocytoma, or oligodendroglioma. Surgical margins refer to the edge or border of the tissue removed in cancer surgery. qOBM may be able to assess and reveal brain tumor surgical margins in a more safe and reliable manner.
Key facts
- Study ID
- NCT05513859
- Run by
- Emory University
- People needed
- 24
- Starts
- 2024-03-11
- Expected to finish
- 2028-06-23
- Last updated by the study team
- 2026-04-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age >= 18 years
- Craniotomy is indicated for tumor management
- Surgery planned for 14 or fewer days from enrollment
- Evidence of a personally signed informed consent indicating that the subject is aware of the neoplastic nature of the disease and has been informed of the procedures to be followed, the experimental nature of the device evaluation, alternatives, potential risks and discomforts, potential benefits, and other pertinent aspects of study participation.
- A newly discovered brain lesion requiring surgery who imaging is consistent with a new glioblastoma, astrocytoma, or oligodendroglioma or with a progressive histologically proven glioblastoma, astrocytoma, or oligodendroglioma whose management required surgery.
You may not qualify if…
- An individual who meets any of the following criteria will be excluded from participation in this study:
- Patients who are undergoing needle biopsy only
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
Where it is running
- Emory University Hospital/Winship Cancer Institute — Atlanta, Georgia, United States
Full record on ClinicalTrials.gov
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