PK Subtrial in Adolescent Patients With HAE Type I or II Participating in the KVD900-302 Trial

Completed · Phase 3

Conditions studied: Hereditary Angioedema

In brief

This is a multicenter pharmacokinetic (PK) subtrial to investigate the PK profile of KVD900 (sebetralstat) in adolescent patients 12 to 17 years of age with Hereditary Angioedema (HAE) type I or II.

Key facts

Study ID

NCT05511922

Run by

KalVista Pharmaceuticals, Ltd.

People needed

11

Starts

2022-10-24

Expected to finish

2026-05-27

Last updated by the study team

2026-06-08

Who can join

Age: 12 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female adolescent patient 12 to 17 years of age at the time of enrollment and during sample collection in this PK subtrial.
• Patient is currently participating in KVD900-302.
• Patient must provide signed informed consent or assent (when applicable), and a legally authorized representative (LAR) must also provide signed informed consent when applicable.
• Patient and LAR are willing and able to provide samples per the requirements of the protocol, including willingness to complete forms and the electronic Diary, obtain and return samples in a timely manner, and obtain samples while within the required age limit.

You may not qualify if…

• Patient has a history of any bleeding disorder or currently taking any anti-coagulant or anti-platelet agent.

Where it is running

• KalVista Investigative Site — Little Rock, Arkansas, United States
• KalVista Investigative Site — San Diego, California, United States
• KalVista Investigative Site — San Diego, California, United States
• KalVista Investigative Site — Santa Monica, California, United States
• KalVista Investigative Site — Centennial, Colorado, United States
• KalVista Investigative Site — Colorado Springs, Colorado, United States
• KalVista Investigative Site — Evansville, Indiana, United States
• KalVista Investigative Site — Overland Park, Kansas, United States
• KalVista Investigative Site — Louisville, Kentucky, United States
• KalVista Investigative Site — Chevy Chase, Maryland, United States
• KalVista Investigative Site — Plymouth, Minnesota, United States
• KalVista Investigative Site — St Louis, Missouri, United States
• KalVista Investigative Site — Charlotte, North Carolina, United States
• KalVista Investigative Site — Cincinnati, Ohio, United States
• KalVista Investigative Site — Toledo, Ohio, United States
• Kalvista Investigative Site — Hershey, Pennsylvania, United States
• KalVista Investigative Site — Dallas, Texas, United States
• KalVista Investigative Site — Layton, Utah, United States
• KalVista Investigative Site — Spokane, Washington, United States
• KalVista Investigative Site — Campbelltown, Australia
• KalVista Investigative Site — Vienna, Austria
• KalVista Investigative Site — Sofia, Bulgaria
• KalVista Investigative Site — Montreal, Canada
• KalVista Investigative Site — Grenoble, France
• KalVista Investigative Site — Scottsdale, Arizona, United States

Full record on ClinicalTrials.gov

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