Intubation Conditions Achieved With Rapid Co-administration of Rocuronium and Propofol Versus Classical Induction

Completed · Phase 4

Conditions studied: Anesthesia

In brief

The purpose of this study is to assess and compare the conditions for tracheal intubation obtained with Modified Time Principle Induction (MTPI) and that obtained with classic induction (CI). This study will compare the efficiency of tracheal intubation with the two induction techniques, as well as evaluate for potential adverse events.

Key facts

Study ID

NCT05509192

Run by

The University of Texas Health Science Center, Houston

People needed

154

Starts

2022-08-17

Expected to finish

2025-01-24

Last updated by the study team

2026-02-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• BMI >30 kg/M2 or Mallampati class III or IV
• Requiring general anesthesia and endotracheal intubation

You may not qualify if…

• Acute and chronic respiratory disorders, including Chronic obstructive pulmonary disease (COPD) and asthma
• American Society of Anesthesiologists (ASA) physical status classification > III
• Emergency surgery
• Induction requiring cricoid pressure
• Patients requiring awake intubation
• Pregnant women
• Patients who require an induction dose of propofol less than 1 mg/kg
• Untreated ischemic heart disease
• Contraindication to mask ventilation
• Allergy to propofol, rocuronium, or Sugammadex
• Induction requiring succinylcholine

Where it is running

• The University of Texas Health Science Center at Houston — Houston, Texas, United States

Full record on ClinicalTrials.gov

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