Ketone Supplementation in Eating Disorders

Completed · Not applicable

Conditions studied: Anorexia Nervosa, Bulimia Nervosa, Atypical Anorexia Nervosa, Atypical Bulimia Nervosa

In brief

This study will investigate the effects of ketone supplementation on eating behavior including drive to binge eat or restrict, mood and anxiety in individuals with anorexia or bulimia nervosa. In addition, the investigators will contrast the effects of active ketone supplementation versus placebo on electroencephalogram (EEG) measurement. All subjects enrolled in the study will undergo EEG on two consecutive days at the beginning of the study, after active ketone supplementation or placebo drink, matched in taste to the ketone drink. Days will be randomized. Thereafter, all subjects will take the ketone supplementation drink for two weeks, twice daily.

Key facts

Study ID

NCT05507008

Run by

University of California, San Diego

People needed

38

Starts

2022-10-13

Expected to finish

2026-07-06

Last updated by the study team

2026-08-03

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must currently meet DSM-5 criteria for Anorexia Nervosa, Bulimia Nervosa, or OSFED Anorexia or Bulimia Nervosa based on the MINI diagnostic interview
• Be medically stable as assessed by a comprehensive medical and behavioral evaluation conducted by a study physician
• English as primary spoken language.
• Ability to respond to EMA questions up to 6x per day within 60 minutes of receiving the message.

You may not qualify if…

• Psychotic illness/other organic brain syndromes, dementia, somatization disorders or conversion disorders
• Current substance abuse or dependence in the past 3 months
• Physical conditions (e.g., diabetes mellitus, pregnancy) known to influence eating or weight
• Medical conditions associated with ketoacidosis: type 1 diabetes mellitus, acute pancreatitis, alcoholic gastritis, peptic ulcer disease, hepatitis or Boerhaave syndrome (esophageal rupture)
• History of significant head trauma
• Indication of intellectual disability or autism spectrum disorder
• Known allergy to any of the KenetikR drink components: D-beta-hydroxybutyric acid (D-BHB), Stevia, Monkfruit, Potassium Bicarbonate, Sodium Bicarbonate Potassium Sorbate or Taste Task Solutions: Sucrose, Potassium Chloride, Sodium bicarbonate.

Where it is running

• University of California San Diego — San Diego, California, United States

Full record on ClinicalTrials.gov

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