The Effect of SAAE on Ventricular Remodeling in PA Patients
Recruiting now · Not applicable
Conditions studied: Primary Aldosteronism
In brief
The study aims to assess the effect of superselective adrenal arterial embolization on ventricular remodeling in primary aldosteronism without lateralized aldosterone secretion by comparing it with spironolactone therapy.
Key facts
- Study ID
- NCT05501080
- Run by
- Second Affiliated Hospital of Nanchang University
- People needed
- 112
- Starts
- 2022-09-01
- Expected to finish
- 2025-12-31
- Last updated by the study team
- 2025-05-16
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- (1) Age 18-60 years old, regardless of gender;
- (2) Blood pressure conditions meet one of the following: 1) Office blood pressure ≥ 140/90mmHg; 2) Ambulatory blood pressure monitoring whole day blood pressure > 130/80 mmHg or daytime blood pressure > 135/85 mmHg;
- (3) After strict drug elution, it met the diagnostic criteria of primary aldosteronism, and bilateral primary aldosteronism was confirmed by adrenal venous sampling;
- (4) No surgical intent or contraindication to surgery and willing to undergo pharmacological treatment or percutaneous superselective adrenal artery embolization;
- (5) The patient or his/her legal representative shall sign the written informed consent approved by the ethics committee before the screening.
You may not qualify if…
- (1) Primary hypertension or secondary hypertension with other causes;
- (2) A woman who is pregnant or lactating, or has a birth plan for the next year;
- (3) There are serious organic diseases, especially liver and kidney dysfunction(eGFR<45 mL/min/1.73 m2);
- (4) Severe allergy to contrast medium;
- (5) Other serious organic diseases, life expectancy < 12 months;
- (6) Adrenal CT showed adenoma.;
- (7) Patients are enrolled or want to participate in other clinical studies. During the enrollment study, the results of this study will be affected.
Where it is running
- The Second Affiliated Hospital of Nanchang University — Nanchang, China (enrolling)
Full record on ClinicalTrials.gov
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