Benefits of Nicotinamide Riboside Upon Cognition and Sleep

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Cognitive Impairment, Sleep Quality

In brief

Poor sleep quality and short sleep duration may be a mechanistic component of cognitive impairment in older adults, associated with a decline in brain-derived neurotrophic factor. Increasing the availability of nicotinamide adenine dinucleotide (NAD+) with supplementation of its precursor, nicotinamide riboside (NR), a form of vitamin B3 may increase the expression of brain-derived neurotrophic factor. This study proposes to examine the benefits of NR supplementation on sleep and cognitive function in older adults with comprehensive subjective and objective measures and to explore its impacts on serum brain-derived neurotrophic factor.

Key facts

Study ID

NCT05500170

Run by

State University of New York at Buffalo

People needed

50

Starts

2023-04-04

Expected to finish

2027-08-30

Last updated by the study team

2025-08-22

Who can join

Age: 65 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Sleep Quality. Pittsburgh Sleep Quality Index (PSQI) global score >5

You may not qualify if…

• Dementia. Veteran Affairs - St. Louis University Mental Status questionnaire (VA-SLUMS) score <20

Where it is running

• Buffalo Veteran Affairs Medical Center — Buffalo, New York, United States (enrolling)
• State University of New York at Buffalo — Buffalo, New York, United States
• University at Buffalo State University of New York — Buffalo, New York, United States

Full record on ClinicalTrials.gov

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