The Effects of Exercise on Quality of Life and Fluid Dynamics in Patients With Aortic Dissection
Withdrawn before enrolling · Not applicable
Conditions studied: Aortic Dissection
In brief
Aerobic exercise and physical activity improve patient health in patients in a variety of aspects of life and disease. It also improves patients' mental well-being and quality of life. However, the safety of this physical activity and its potential benefits remain uncertain for patients after aortic dissection, a tear in the main blood vessel delivering blood to all of the body's organs. The goal of this study is to facilitate the translation of pre-clinical findings by the Principal Investigator and published literature that demonstrates light to moderate exercise is safe and beneficial in patients with thoracic aortic dissection. This will be accomplished by using both imaging-based analyses of aortic wall responses to a 3- month exercise program, patient surveys of quality of life metrics, functional fitness assessments, and clinical outcomes.
Key facts
- Study ID
- NCT05499650
- Run by
- University of Maryland, Baltimore
- People needed
- 0
- Starts
- 2021-10-04
- Expected to finish
- 2024-05-31
- Last updated by the study team
- 2024-11-29
Who can join
Age: 18 and older, up to 88. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 to 88
- History of aortic dissection > 90 Days from acute event
- Previous operative or non-operative management of aortic dissection
- Ability to undergo basic level of activity and exercise
- Able to consent
- Capable of basic communication and recall
You may not qualify if…
- History of surgically untreated Type A Dissection
- Patients within 90 days of acute dissection event
- Patients with unstable coronary artery disease
- Patients with severe cardiopulmonary disability (class III/IV heart failure and/or ejection fraction < 20%),
- Patients with malignant hypertension
- Patients with previous stroke with significant persistent motor deficit
- Patients with any orthopedic or podiatric conditions altering their ambulation status will be excluded.
- Patients with any other health reasons which preclude exercise tolerance such as morbid obesity (BMI > 39 kg/m2), severe hepatic dysfunction, critical aortic stenosis, or active pericarditis or myocarditis.
- Patients with allergies to iodinated contrast as would be used for CT scan surveillance.
- Patients who have significant barriers for reliable follow-up
- Patients with significant cognitive impairment, or who are unable to carry-out basic communication and recall.
- Patients belonging to vulnerable populations
- Patients with connective tissue disorders such as Marfan's syndrome, Ehlers-Danlos Type IV, or Loesz-Dietz syndrome
- Patients who are unable or unwilling to consent
- Age less than 18 or over 88.
Where it is running
- Baltimore VA Medical Center — Baltimore, Maryland, United States
- University of Maryland Medical Center — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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