Neuroimaging Sleep and Mood in Depression

Completed · Not applicable

Conditions studied: Major Depression

In brief

This study will investigate how sleep and mood are related in patients with depression and in healthy controls. It will use MRI-based measures of brain function to determine how neural systems are modulated by sleep and sleep deprivation, and its links to mood in depression.

Key facts

Study ID

NCT05497414

Run by

Boston University Charles River Campus

People needed

81

Starts

2022-01-31

Expected to finish

2024-03-15

Last updated by the study team

2026-07-27

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult aged 18-80
• Inclusion criteria for patient cohort only:
• Current diagnosis of major depressive disorder

You may not qualify if…

• Must not have ferrous metal implanted in head or body
• Must have no history of major head trauma
• Must not have implanted electronic devices (e.g., pacemaker, neurostimulator)
• Must not be pregnant, suspect they are pregnant, or seeking to become pregnant
• Must not be claustrophobic
• Must have no piercings or jewelry that cannot be removed
• Weight less than 250 pounds
• No lifetime history of schizophrenia or any other psychosis disorder, substantial intellectual disability, bipolar disorder, post-traumatic stress disorder or obsessive compulsive disorder
• No alcohol or substance abuse or dependence within the past 6 months
• No significant personality dysfunction
• Must not indicate significant suicide risk.
• Must not be taking medications that significantly affect sleep, psychiatric function, blood/vascular function, or anti-inflammatory medications (other than minor NSAID use).

Where it is running

• Boston University — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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