Reference Values for Videofluoroscopic Measures of Swallowing

Enrolling by invitation · Not applicable

Conditions studied: Dysphagia, Oropharyngeal

In brief

Dysphagia (swallowing impairment) is a serious health condition seen in many age-related disease and injury processes. Although videofluoroscopy (VF) is an international "gold standard" dysphagia diagnostic exam, there is a paucity of available normative physiologic VF reference values in healthy adults across the age span to guide interpretation of these examinations. In this project, the investigators will extend previous work on the quantitative measurement of swallowing physiology from VF examinations to establish reference values for swallowing in healthy adults, and to identify clinical decision point values for differentiating healthy swallowing across the age span from disordered swallowing in several high-risk clinical populations to study dysphagia.

Key facts

Study ID

NCT05497219

Run by

University Health Network, Toronto

People needed

580

Starts

2022-11-15

Expected to finish

2027-07-31

Last updated by the study team

2026-05-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy Volunteers: no history of swallowing difficulties.
• Clinical cohorts: physician confirmed diagnosis of the condition of interest plus symptoms of swallowing difficult, defined as a score >/=200 on the Sydney Swallow Questionnaire.

You may not qualify if…

• cognitive communication difficulties that may hinder comprehension of the study documents
• known allergies to latex, due to the possibility that these items will come into contact with the oral mucosa during data collection
• current pregnancy

Where it is running

• University of Florida — Gainesville, Florida, United States
• University of Cincinnati Medical Center — Cincinnati, Ohio, United States
• The Ohio State University — Columbus, Ohio, United States
• McMaster University — Hamilton, Ontario, Canada
• University Health Network — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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