Exparel Use in Peripheral Nerve Blocks and Local Infiltration for Foot and Ankle Surgery

Completed · Phase 4

Conditions studied: Pain, Postoperative, Pain, Acute Postoperative, Ankle Fractures, Ankle Injuries and Disorders

In brief

Liposomal Bupivacaine (Exparel) has been recently studied as the active agent utilized in various nerve block. Due to its liposomal form allowing for extended delivery, Exparel has been used in various peri-operative nerve blocks among multiple orthopaedic specialties in hopes of achieving improved pain control and decreased opioid use. This study compares the efficacy and effect on opioid use of peripheral nerve blocks and local infiltration with and without Exparel in patients undergoing foot and ankle surgery.

Key facts

Study ID

NCT05494645

Run by

St. Luke's Hospital, Pennsylvania

People needed

248

Starts

2022-03-01

Expected to finish

2023-01-31

Last updated by the study team

2026-04-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients undergoing elective orthopaedic foot and ankle surgery at a single institution
• English speaking
• Able to provide consent to surgery and study participation

You may not qualify if…

• Non-elective or emergent foot and ankle surgery
• Non-english speaking
• Does not possess medical decision making capacity

Where it is running

• St. Luke's University Health Network — Bethlehem, Pennsylvania, United States

Full record on ClinicalTrials.gov

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