The Heartland Study
Recruiting now
Conditions studied: Pregnancy Related, Pregnancy Complications, Birth Defect, Gestational Age and Weight Conditions, Spontaneous Abortion, Miscarriage, Exposure to Herbicides
In brief
The Heartland Study is a prospective, observational study that will enroll up to 2,600 pregnant participants across the Heartland States in the U.S.. The objective of the Heartland Study is to address major knowledge gaps concerning the health effects of herbicides on maternal and infant health. The study is being conducted to evaluate the associations between environmental exposures to herbicides during and after pregnancy and reproductive health outcomes. The study is measuring multiple biomarkers of herbicide exposure among pregnant Midwesterners and their partners to evaluate associations with pregnancy and childbirth outcomes, epigenetic biomarkers of exposure, and child development.
Key facts
- Study ID
- NCT05492708
- Run by
- Heartland Health Research Alliance
- People needed
- 2600
- Starts
- 2020-01-11
- Expected to finish
- 2029-01-01
- Last updated by the study team
- 2025-06-29
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Pregnant persons ages 18 or older at time of consent who are ≤20+6 weeks pregnant. Best clinical estimate of gestational age will be utilized for recruitment purposes. Enrollment in the first trimester (≤ 13 + 6) is preferred, but anyone ≤ 20 +6 is permitted.
- Living in one of the 13 Heartland Study region states at the time of enrollment (Arkansas, Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota, or Wisconsin) Optional inclusion of the putative biological father
You may not qualify if…
- Participants who are not fluent in and/or do not fully understand, read, write, or speak the English language.
- Other inability to provide informed consent to participate
Where it is running
- Indiana University Medical Center — Indianapolis, Indiana, United States (enrolling)
- University of Iowa Health Care — Iowa City, Iowa, United States (enrolling)
- Marshfield Clinic — Marshfield, Wisconsin, United States (enrolling)
- Gundersen Health — La Crosse, Wisconsin, United States
Full record on ClinicalTrials.gov
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