Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI

Recruiting now · Not applicable

Conditions studied: Spinal Cord Injuries, Neuropathic Pain, Neurological Injury, Pain

In brief

The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain. For this, the researchers are recruiting 15 individuals with neuropathic pain due to spinal cord injury to participate in the reflex training procedure. The study involves approximately 50 visits with a total study duration of about 6.5 months (3 months for baseline and training phases followed by 1 month and 3 month follow-up visits).

Key facts

Study ID: NCT05492188
Run by: Medical University of South Carolina
People needed: 15
Starts: 2023-03-27
Expected to finish: 2026-10-01
Last updated by the study team: 2025-10-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

neurologically stable (>1 year post SCI)
medical clearance to participate
ability to stand with or without an assistive device for at least 3 minutes at a time
expectation that current medication will be maintained without change for at least 3 months (stable use of anti-spasticity medication is accepted)
For participants with neuropathic pain, the area of neuropathic pain must include lower leg.

You may not qualify if…

motoneuron injury
known cardiac condition
medically unstable condition (incl. pregnancy)
cognitive impairment
uncontrolled peripheral neuropathy
frequent use of electrical spinal stimulation (either transcutaneous or epidural) for pain treatment
daily use of electrical stimulation to the leg
complete lack of cutaneous sensation around foot.

Where it is running

Medical University of South Carolina — Charleston, South Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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