Assessing the Impact of Exercise Based Intensive Interdisciplinary Pain Treatment (IIPT) on Endogenous Pain Modulation in Youth With Chronic Pain Syndromes
Completed
Conditions studied: Chronic Pain Syndrome, Fibromyalgia, Chronic Headache Disorder, Functional Abdominal Pain Syndrome, Complex Regional Pain Syndromes
In brief
This work will answer two critical questions: 1) Does intensive interdisciplinary pain treatment (IIPT) involving aerobic exercise help normalize pain processing in youth with chronic pain syndromes and 2) Are aerobic fitness levels and the ability to modulate pain inter-related? Currently, medications are ineffective for improving pain and disability in youth with chronic pain syndromes and identifying non-pharmacologic treatments, such as IIPT, that help strengthen the nervous system's ability to modulate or turn pain signals down will improve outcomes and quality of life for youth suffering from chronic pain. This study will help determine whether exercise based IIPT leads to physiologic improvements in how pain is processed, specifically if youth with chronic pain can better turn pain down during the offset analgesia test after an exercise based IIPT treatment, and also help elucidate the link between a child's aerobic fitness and their ability to modulate pain.
Key facts
- Study ID
- NCT05491499
- Run by
- Boston Children's Hospital
- People needed
- 43
- Starts
- 2022-10-17
- Expected to finish
- 2023-11-30
- Last updated by the study team
- 2024-06-26
Who can join
Age: 10 and older, up to 17. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- i) presence of allodynia in either upper extremity
- ii) a history of central nervous system, heart, kidney, liver and respiratory system diseases, and psychiatric disorders (e.g., bipolar, conversion, psychosis)
- iii) reported consumption of alcohol, cannabis or tobacco products
- iv) unable to read English or follow testing instructions
- v) intolerant to the thermal test stimulus, or vi) no pain reported at maximum stimulus (48ºC).
Where it is running
- Boston Children's Hospital at Waltham — Waltham, Massachusetts, United States
Full record on ClinicalTrials.gov
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