MiECC Versus Conventional Cardiopulmonary Bypass in Cardiac Surgery (MiECS)
Recruiting now · Not applicable
Conditions studied: Coronary Artery Disease, Aortic Valve Stenosis, Extracorporeal Circulation; Complications
In brief
MiECS is one of the largest multicentre randomised controlled trials on extracorporeal circulation conducted under the auspices of Minimal Invasive Extracorporeal Technologies International Society (MiECTiS). It is designed to ultimately address the emerging effectiveness of MiECC systems in the light of modern perfusion practice worldwide. The primary hypothesis is that MiECC, as compared to conventional CPB (cCPB), reduces the proportion of patients experiencing serious perfusion-related postoperative morbidity after cardiac surgery. The study will be led by the Clinical Research Unit of the Special Unit for Biomedical Research and Education (SUBRE), Aristotle University of Thessaloniki School of Medicine in Greece (AUSoM) with Chief Investigator Professor Kyriakos Anastasiadis, who is a key-opinion-leader in the field of MiECC, founder and Executive Board of MiECTiS.
Key facts
- Study ID
- NCT05487612
- Run by
- Aristotle University Of Thessaloniki
- People needed
- 1300
- Starts
- 2022-05-26
- Expected to finish
- 2029-03-31
- Last updated by the study team
- 2026-03-30
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All patients undergoing any elective or urgent coronary artery bypass grafting (CABG), aortic valve replacement (AVR) or CABG+AVR surgery using extracorporeal circulation without circulatory arrest.
You may not qualify if…
- Requirement for emergency or salvage operation.
- Requirement for major aortic surgery (e.g. aortic root replacement).
- Contraindication or objection (e.g. Jehovah's Witnesses) to transfusion of blood products.
- Congenital or acquired platelet, red cell or clotting disorders (patients with iron deficient anaemia will not be excluded).
- Inability to give informed consent for the study (e.g. learning or language difficulties).
Where it is running
- Department of Cardiovascular Surgery, Izmir Bakırçay University, Faculty of Medicine — Izmir, Turkey (Türkiye) (enrolling)
- Department of Cardiovascular Surgery, Faculty of Medicine, Recep Tayyip Erdoğan University — Rize, Turkey (Türkiye) (enrolling)
- Cardiothoracic Department AHEPA University Hospital — Thessaloniki, Greece (enrolling)
- Department of Cardiac Surgery GVM Anthea Hospital — Bari, Italy (enrolling)
- Perfusion Services University Health Network, Toronto General Hospital — Toronto, Canada (enrolling)
- Department of Cardiovascular Surgery, Ankara City Hospital — Ankara, Turkey (Türkiye)
- Department of Cardiac Surgery, Royal Papworth Hospital — Cambridge, United Kingdom
- Deparment of Cardiac Surgery, Castle Hill Hospital — Hull, United Kingdom
- Department of Cardiothoracic Surgery, Hammersmith Hospital — London, United Kingdom
- Department of Cardiac Surgery — Coswig, Germany
- Department of Thoracic and Cardiovascular Surgery, University Medical Centre Goettingen — Göttingen, Germany
- Department of Cardiothoracic and Vascular Surgery, Ulm University Hospital — Ulm, Germany
- Department of Cardiac Surgery GVM Maria Eleonora Hospital — Palermo, Italy
Full record on ClinicalTrials.gov
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