The ECMO-Free Trial

Completed · Not applicable

Conditions studied: Extracorporeal Membrane Oxygenation Complication

In brief

Decannulation from venovenous extracorporeal membrane oxygenation (VV-ECMO) at the earliest and safest time would be expected to improve outcomes and reduce cost. Daily assessments for readiness to liberate from therapies have demonstrated success in other realms of critical care. A recent single-center study demonstrated that a protocolized daily assessment of readiness for liberation from VV-ECMO was feasible and did not raise any major safety concerns, but the effect of this protocolized daily assessment on clinical outcomes remains unclear. Further, the manner in which ECMO is provided, weaned, and discontinued varies significantly between centers, raising persistent concerns regarding widespread adoption of protocolized daily assessment of readiness for liberation from VV-ECMO. Data from large a randomized controlled trial is needed to compare the effects of a protocolized daily assessment of readiness for liberation from VV-ECMO versus usual care on duration of ECMO support and other clinical outcomes.

Key facts

Study ID

NCT05486559

Run by

Vanderbilt University Medical Center

People needed

225

Starts

2022-09-07

Expected to finish

2026-05-08

Last updated by the study team

2026-06-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient receiving VV-ECMO
• Patient is located in a participating unit of an adult hospital

You may not qualify if…

• Patient is pregnant
• Patient is a prisoner
• Patient is < 18 years old
• Participant is receiving ECMO as bridge to transplant
• Participant is receiving a hybrid configuration that includes an arterial cannula
• Patient has received VV-ECMO for > 48 hours

Where it is running

• UC San Diego Health — San Diego, California, United States
• Stanford University — Stanford, California, United States
• Hennepin County Medical Center — Minneapolis, Minnesota, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• Baylor University Medical Center — Dallas, Texas, United States
• Texas Tech University Health Sciences Center of El Paso — El Paso, Texas, United States
• University of Utah Health — Salt Lake City, Utah, United States
• Toronto General Hospital — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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