The Effect of NAD Supplementation on Brain Vascular Health in Aging
Recruiting now · Phase 4 · Has a placebo group
Conditions studied: Aging
In brief
Daily consumption of one of the forms of Vitamin B3, the Nicotinamide Riboside (NR), energizes the body and combats cellular aging. This study is designed to test whether NR can also improve brain health and memory.
Key facts
- Study ID
- NCT05483465
- Run by
- University of Oklahoma
- People needed
- 214
- Starts
- 2023-05-03
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-04-01
Who can join
Age: 60 and older, up to 85. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age ≥60 and ≤85 years of age
- Adequate hearing and visual acuity to participate in the examinations
- Ability to read and write in English
- Competence to provide informed consent.
- Mini-Mental State Exam score ≥24
You may not qualify if…
- Vision or hearing impairment that would impair the ability to complete study assessments
- Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer
- Cerebrovascular accident other than TIA within 60 days prior to Visit 0
- Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuse
- Abnormal kidney function (creatinine >2mg/dL or EGFR <30mL/min) by most recent labs within 6 months prior to Visit 0
- Elevated liver enzymes (AST and/or ALT above x2 upper limit of normal) by most recent labs within 6 months prior to Visit 0
- Treatment with other NAD enhancers (Nicotinamide riboside or nicotinamide mononucleotide) within 4 weeks prior to randomization.
- Any other medical condition which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol
Where it is running
- University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States (enrolling)
Full record on ClinicalTrials.gov
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