A Diagnostic Test for Dementia With Lewy Bodies

Running, not enrolling

Conditions studied: MCI-AD, Early Stage Alzheimer's Disease, MCI-DLB, Early Stage Dementia With Lewy Bodies

In brief

The Syn-D Study will be evaluating α-synuclein in patients with suspected MCI-AD and MCI-DLB. Using a simple diagnostic test will improve clinical accuracy in diagnosing, earlier diagnosis, and distinguish between neurodegenerative diseases.

Key facts

Study ID

NCT05479552

Run by

CND Life Sciences

People needed

80

Starts

2022-08-15

Expected to finish

2025-10-31

Last updated by the study team

2025-01-15

Who can join

Age: 50 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and women 50 to 85 years of age
• Clinical diagnosis of mild cognitive impairment, and a presumed etiology of DLB or AD at enrollment

You may not qualify if…

• Clinical evidence of severe peripheral vascular disease (Fazekas score of ≥ 3, or a large vessel stroke of ≥ 2 cm, history of ulceration, poor wound healing, vascular claudication)
• Clinically active coronary artery or cerebrovascular disease
• Current smoker or alcoholism
• History of allergic reaction to local anesthesia (for biopsy collection)
• Use of anticoagulants (aspirin or Plavix alone is allowed)
• Significantly impaired wound healing or history of scarring or keloid formation

Where it is running

• CND Life Sciences — Scottsdale, Arizona, United States
• University of California San Diego — La Jolla, California, United States
• CenExel RMCR — Englewood, Colorado, United States
• University of Miami — Boca Raton, Florida, United States
• Neurology One — Winter Park, Florida, United States
• Ochsner Research — New Orleans, Louisiana, United States
• Mass General Hospital — Boston, Massachusetts, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Headlands Research — Plymouth, Massachusetts, United States
• University of Michigan — Ann Arbor, Michigan, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• University of Utah — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.