Neural Mechanisms of Clinically Designed Improvisatory Music for Alzheimer's Disease
Enrolling by invitation · Not applicable
Conditions studied: Alzheimer Disease
In brief
Clinically Designed Improvisatory Music (CDIM) is a form of improvised music based on calm-inducing sound parameters which brought relief to our cohort of neurology patients. As a direct sound-based approach, CDIM does not rely on autobiographical memory and may have wider applicability and generalizability. We wish to examine if CDIM decreases anxiety in 15 cognitively healthy individuals and 15 Alzheimer Disease patients with anxiety (AD-A).
Key facts
- Study ID
- NCT05477862
- Run by
- Northwestern University
- People needed
- 30
- Starts
- 2023-09-01
- Expected to finish
- 2026-12-15
- Last updated by the study team
- 2026-08-10
Who can join
Age: 55 and older, up to 100. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Cognitively healthy individuals
- Cognitively healthy control participants evaluated through the Northwestern Mesulam Center. BAI > 8.
- Exclusion Criteria: hearing loss
- Individuals with mild to moderate Alzheimer's disease
- This group will similarly be recruited through the Mesulam Center. All individuals recruited by the research Core at the center are well characterized tests standardized across all NIH funded Alzheimer Centers across the nation. Individuals with mild to moderate neurocognitive disorder due to AD will have an MMSE greater than >15 and Clinical Dementia Rating (CDR) between 0.5 and 2.. They will also have a history of neurocognitive-related agitation/anxiety, and a Beck Anxiety Index (BAI) or Rating for Anxiety in Dementia (RAID) greater than 8, suggestive of at least a mild level of anxiety.
- Exclusion criteria: MMSE<15, CDR>2, hearing loss
Where it is running
- Mesulam Center for Cognitive Neurology and Alzheimer's Disease — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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