Arginine Metabolism in Youth With Type 2 Diabetes

Recruiting now · Not applicable

Conditions studied: Type 2 Diabetes

In brief

Type 2 diabetes (T2D), once considered only "a disease of older ages," is now a significant public health concern in youth. Although it is characterized by insulin resistance and impaired insulin secretion, its precise etiology and pathogenesis are not yet fully understood. This study aims to (1) explore arginine metabolism in youth with T2D via safe, minimally invasive kinetic experiments using stable isotope tracers and targeted metabolomics, and (2) determine the effect of exogenous arginine administration on β-cell function in youth with T2D, potentially supporting the use of this safe, low-cost, and readily available nutrient to improve pediatric diabetes outcomes.

Key facts

Study ID

NCT05477134

Run by

Baylor College of Medicine

People needed

30

Starts

2023-02-06

Expected to finish

2027-08-31

Last updated by the study team

2026-01-27

Who can join

Age: 12 and older, up to 20. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Youth with type 2 diabetes and healthy controls who meet other inclusion criteria outlined below.
• Age and pubertal stage criteria (12- to 20-year-old girls who are postmenarchal, and 14- to 20-year-old boys who are at Tanner stage 5 genitalia),
• Additional criteria for youth with diabetes: i. diagnosis of T2D, and ii. diabetes duration between 3 months and 10 years.

You may not qualify if…

• Previous history of diabetic ketoacidosis (DKA)
• Poorly controlled diabetes defined as HbA1c >7.5%,
• Abnormal liver, thyroid, gonadal or adrenal functions,
• Renal insufficiency defined by eGFR (estimated glomerular filtration rate) <90 mL/min/1.73 m2,
• Any glucose lowering medications except metformin, insulin and liraglutide
• (7) Any medication use that will likely to interfere amino acid metabolism, (8) Any hormonal replacement therapy, and (9) Pregnancy.

Where it is running

• Texas Children's Hospital / Baylor College of Medicine — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.