Minocycline for Chronic Autoimmune Uveitis

Recruiting now · Phase 1/Phase 2

Conditions studied: Minocycline, Uveitis, Retinal Degeneration

In brief

Autoimmune uveitis is one kind of non-infectious, sight-threatening, relapsing and severe ocular disease. Approximately 20%-25% autoimmune uveitis patients suffer from the dilemma of blindness for the chronic and persistent inflammatory state in the eyes, which results in continuous destroy in the structure of the eyes and gradually leads to irreversible damage on visual function. However, it shows limiting efficacy of current treatment including glucocorticoids, immunosuppressant and biologics for chronic autoimmune uveitis. Minocycline has been regarded to have anti-apoptosis and immunemodulatory function for decades and it has been illustrated to be beneficial in several neuro-degenerative and neuro-inflammatory diseases. This trial aims to investigate the efficacy and safety of minocycline for chronic autoimmune uveitis with retinal degenerative changes.

Key facts

Study ID

NCT05474729

Run by

Sun Yat-sen University

People needed

10

Starts

2021-12-01

Expected to finish

2026-12-31

Last updated by the study team

2023-04-18

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participant diagnosed of autoimmune diseases with visual function damage (decrease of BCVA, loss of retinal structure)
• Participant aged from 18-60 years old.
• Participant that signed the informed consent document and is able to complete the following visits.

You may not qualify if…

• Participant is allergy to minocycline or tetracyclines.
• Participant has no contraindications of minocycline or tetracyclines.
• Participant has an abnormal function of liver, heart, kidney and thyroid.
• Participant is using glucocorticoids, immunosuppressants or biologics.
• Female that is pregnant, breast-feeding or planning to become pregnant.
• Participant that is currently using other medications for other diseases.

Where it is running

• Zhongshan Ophthalmic Center — Guangzhou, Guangdong, China (enrolling)

Full record on ClinicalTrials.gov

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