Estimating Risk of Respiratory Infections Attributable to CFTR Heterozygosity

Recruiting now

Conditions studied: Carrier State, Respiratory Infections

In brief

A research team member will brush the inferior surface of the subjects' middle turbinate (nasal cavity) using a cytology brush to obtain the cells needed to perform our functional respiratory assays. An individual trained in phlebotomy will draw one 3 ml lavender top tube of blood to test c-reactive protein, calprotectin, and lactoferrin. They will also draw a 5 ml gold top serum separator tube of blood to test fibroblast growth factor-19. The participant will answer questions from the baseline survey and report their current medications interview-style with the research team member.

Key facts

Study ID

NCT05474430

Run by

Philip Polgreen

People needed

160

Starts

2021-12-20

Expected to finish

2026-07-01

Last updated by the study team

2026-01-07

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Currently sick with a respiratory infection
• Prisoner Status
• Unable to provide own written, informed consent

Where it is running

• University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States (enrolling)

Full record on ClinicalTrials.gov

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