Association Between Driving Transpulmonary Pressure and Extravascular Lung Water in Patients with ARDS

Recruiting now

Conditions studied: Acute Respiratory Distress Syndrome

In brief

Intubated patients with the acute respiratory distress syndrome (ARDS) are usually treated with protective ventilation limiting plateau pressure below 30 centimeter of water (cmH2O) and, if possible, a driving pressure under 15 cmH2O. However, these airway pressures might not reflect the actual pressure applied to the lung. Transpulmonary pressure is the difference between airway pressure and pleural pressure, the latter is estimated by the esophageal pressure, and so it better reflects the ventilatory induced lung injury (VILI). One of the consequences of the VILI is a increase of pulmonary edema and it could be estimated by the extravascular lung water, obtained by trans-pulmonary thermodilution. So it could exist a link between the driving trans-pulmonary pressure and the extravascular lung water.

Key facts

Study ID

NCT05474196

Run by

Bicetre Hospital

People needed

100

Starts

2022-02-01

Expected to finish

2025-09-01

Last updated by the study team

2025-02-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Acute respiratory distress syndrome (ARDS)
• Monitoring with a transpulmonary thermodilution device
• Esophageal pressure monitoring

You may not qualify if…

• Legal protection measures
• Pregnancy
• Contra-indications of esophageal catheter : esophageal varicose, severe coagulopathy

Where it is running

• Medical Intensive Care Unit, Bicêtre Hospital — Le Kremlin-Bicêtre, France (enrolling)

Full record on ClinicalTrials.gov

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