Reducing Hypotensive Anesthesia Use With TXA During Orthognathic Surgery

Completed · Phase 4

Conditions studied: Hypotension During Surgery, Blood Loss, Surgical

In brief

This prospective study will analyze the need for deliberate hypotensive anesthesia (DHA) during orthognathic surgery when tranexamic acid (TXA) is administered. DHA has been proven to be effective although it comes with multiple risks related to organ hypoperfusion including kidney injury, stroke, and cardiac ischemia. Therefore, it may be potentially safer for patients to avoid deliberate hypotensive anesthesia if TXA alone adequately controls blood loss and provides adequate surgical site visualization.

Key facts

Study ID

NCT05474027

Run by

University of Alabama at Birmingham

People needed

115

Starts

2022-11-11

Expected to finish

2025-12-01

Last updated by the study team

2026-05-27

Who can join

Age: 12 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Bimaxillary orthognathic surgery completed at UAB Highlands Hospital

You may not qualify if…

• History of hypertension or previously diagnosed cardiac problems
• Bleeding diathesis
• TXA medically contraindicated

Where it is running

• UAB Hospital-Highlands — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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