Descriptive Analysis of Serum Immunological Markers During an Euploid Frozen Embryo Transfer in a Natural Cycle.
Recruiting now
Conditions studied: Infertility, Female
In brief
To describe the peripheral serum levels of the anti-inflammatory cytokines IL-4 (Interleukin-4), IL-10 (Interleukin-10), TGF-ß1 (Transforming Growth Factor beta1), the pro-inflammatory cytokines IL-17 (Interleukin-17), IFγ (Interferon Gamma) and the immune mediator PIBF (Progesterone-Induced Blocking Factor) along a single frozen euploid blastocyst transfer in a natural cycle (NC) or Hormone Replacement Therapy (HRT).
Key facts
- Study ID
- NCT05473273
- Run by
- ART Fertility Clinics LLC
- People needed
- 40
- Starts
- 2023-04-24
- Expected to finish
- 2026-12-30
- Last updated by the study team
- 2026-06-25
Who can join
Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Women aged 18 years to 40 years
- Having at least one good quality (grade A or B for inner mass cell and trophectoderm) day 5 or 6 chromosomally normal cryopreserved blastocyst available for transfer
- Single embryo transfer in a natural cycle (NC) or an Hormone Replacement Therapy (HRT) protocol
- Fresh ejaculate used for fertilization
You may not qualify if…
- Body mass index lower than 18.5 or equal or higher than 29 kg/m2
- Endometriosis or adenomyosis suspected by medical history (dysmenorrhea, dyspareunia, heavy or prolonged menstrual bleeding (> 8 days), chronic pelvic pain, catamenial rectal or bladder symptoms) or diagnosed by imaging (magnetic resonance imaging or ultrasonography)
- Uterine abnormalities
- Hydrosalpinx
- Insulin resistance or diabetes mellitus diagnosed by HbA1c 5.7 %
- Antiphospholipid syndrome
- Polycystic ovarian syndrome according to Rotterdam criteria: presence of at least two of the following: irregular cycles (< 21 or > 35 days or < 8 cycles a year), biochemical or clinical hyperandrogenism, ovarian ultrasound morphology (> 20 follicles per ovary on transvaginal scan) or Anti-mullerian hormone > 5,98 ng/ml
- History of recurrent miscarriage, defined as the loss of 2 or more pregnancies according to ESHRE guidelines
- History of implantation failure, considered as the lack of pregnancy after the transfer of 2 good-quality (grade A or B for inner mass cell and trophectoderm (29)) euploid embryos
- History or suspicion of Asherman syndrome
- Autoimmune disease
- Couple first degree consanguineous
Where it is running
- ART Fertility Clinics LLC — Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates (enrolling)
Full record on ClinicalTrials.gov
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