Continuation of the nuMoM2b Heart Health Study
Enrolling by invitation
Conditions studied: Cardiovascular Diseases
In brief
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in U.S. women at all ages, and large knowledge gaps exist in CVD predictive and preventative strategies for women. The nuMoM2b Heart Health Study (nuMoM2b-HHS) has followed a demographically diverse cohort of women enrolled and richly phenotyped during their first pregnancy, with data and biospecimens prospectively collected for up to 7 years thereafter. The overarching scientific goal of this study is to define the relationship between adverse pregnancy outcomes (APOs) and CVD to optimize CVD prediction, prevention, and treatment strategies for women. Continued follow-up of this observational cohort, building on a foundation of existing high-quality data, biospecimens, and administrative structures with a robust framework for ancillary study development and implementation, provides a unique opportunity to address knowledge gaps regarding the early mechanisms and trajectory of CVD in women.
Key facts
- Study ID
- NCT05472597
- Run by
- RTI International
- People needed
- 4048
- Starts
- 2022-11-29
- Expected to finish
- 2027-01-01
- Last updated by the study team
- 2026-07-01
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: accepted.
Where it is running
- University of California, Irvine Medical Center — Orange, California, United States
- Christiana Care Health Services — Newark, Delaware, United States
- Northwestern University — Chicago, Illinois, United States
- Indiana University — Indianapolis, Indiana, United States
- Columbia University Medical Center — New York, New York, United States
- Case Western Reserve University/The MetroHealth System — Cleveland, Ohio, United States
- Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
- Pennsylvania Hospital — Philadelphia, Pennsylvania, United States
- Magee Womens Research Institute — Pittsburgh, Pennsylvania, United States
- Intermountain Medical Center — Murray, Utah, United States
- McKay-Dee Hospital — Ogden, Utah, United States
- Utah Valley Hospital — Provo, Utah, United States
- University of Utah — Salt Lake City, Utah, United States
- LDS Hospital — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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