MRI Study of Subjects with ASD, Their Relatives and TD
Recruiting now
Conditions studied: Autism Spectrum Disorder
In brief
This project is structured around a central study called "Study of genetic factors involved in autism and related conditions ("Genes and Autism" study, sponsor: INSERM). This study explores clinical and genetic aspects of ASD (autism spectrum disorders) and is complemented with several ancillary studies (such as this one) which will use the data of the main study and will allow an extensive review of phenotypes associated with ASD. In this ancillary study, we will go on the acquisition of anatomical, diffusion and functional MRI in subjects with ASD, relatives and controls. Our group has already performed several neuroanatomical studies of ASD. IWe recruited since 2010 more than 600 subjects (proponents, relatives and controls) to better understand the implication of brain abnormalities in ASD. This study involves specialized teams in neuroiamging based at INSERM, NeuroSpin (CEA), Robert Debré Hospital (APHP) and Pasteur Institute Our main objective is to identify structural, connectivity and functional peculiarities in subjects with ASD Secondary objectives include: * the identification of familial heritability patterns of ASD * correlate data obtained in brain imaging with genetic data * assess specificity and statistical reproducibility of the obtained results
Key facts
- Study ID
- NCT05470088
- Run by
- Institut National de la Santé Et de la Recherche Médicale, France
- People needed
- 1000
- Starts
- 2022-03-13
- Expected to finish
- 2039-09-13
- Last updated by the study team
- 2025-03-13
Who can join
Age: 2 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- for patients:
- being included in the main study "C16-89 - Study of genetic factors involved in ASD and related disorders"
- having an ASD fulfilling DSM-5 diagnostic criteria (APA, 2012). Diagnosis will be done by a clinical expert, with the support of structured instruments (ADI-R, ADOS-2)
- having at least 24 Months
- being affiliated with the French health insurance
- having signed the informed consent (by proposant or by legal tutors if the subject is <18 or under legal custody)
- for relatives
- being included in the main study "C16-89 - Study of genetic factors involved in ASD and related disorders"
- having at least 24 Months
- being affiliated with the French health insurance
- having signed the informed consent (by proposant or by legal tutors if the subject is <18 or under legal custody)
- for controls
- being included in the main study "C16-89 - Study of genetic factors involved in ASD and related disorders"
- having at least 24 Months
- being affiliated with the French health insurance
- having signed the informed consent (by proposant or by legal tutors if the subject is <18 or under legal custody)
- Non-inclusion criteria:
- for all subjects
- severe mental retardation (IQ<35 or developmental age<18 months)
- medical condition (either psychiatric or physical) not compatible with an inclusion
- MRI counter indication
- Current pregnancy or breastfeeding, assessed by questionnaire
- Not willing to be informed of a brain abnormality diagnosed with MRI
- for the relatives
- discovery of non filiation during the genetic analyses
You may not qualify if…
- for patients: ASD diagnosis not confirmed by assessments after the inclusion
- for all subjects: discovery of a counter indication to MRI during the exam (e.g. claustrophobia)
Where it is running
- APHP, Hôpital Robert Debré — Paris, France (enrolling)
- NeuroSpin neuroimaging platforme — Gif-sur-Yvette, France
Full record on ClinicalTrials.gov
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