Comparing Two Prophylactic Antibiotic Protocols in Women With Term Prolonged Pre-labor Rupture of Membrane and Preterm Labor

Recruiting now · Not applicable

Conditions studied: Preterm Labor With Preterm Delivery, Premature Rupture of Membranes Prolonged

In brief

This randomized prospective trial aimed to compare 2 prophylactic antibiotic regiment (ampicillin alone versus ampicillin plus gentamycin) in term prolonged pre-labor rupture of membrane and in preterm deliveries and examine related obstetrical outcome and infectious morbidity

Key facts

Study ID

NCT05469984

Run by

Western Galilee Hospital-Nahariya

People needed

600

Starts

2022-11-25

Expected to finish

2025-09-26

Last updated by the study team

2025-08-06

Who can join

Age: 18 and older, up to 48. Sex: female. Healthy volunteers: accepted.

You may not qualify if…

• GBS carrier
• preterm premature rupture of membrane for conservative treatment
• intra-uterine fetal death fetal major anomaly
• drug allergy for the antibiotic in use in this study
• women receiving antibiotic treatment for other infection such as urinary tract infection

Where it is running

• Galil Medical Center — Nahariya, Israel (enrolling)

Full record on ClinicalTrials.gov

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