The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults

Recruiting now · Not applicable

Conditions studied: Glucose Intolerance, Exercise, Vascular Function

In brief

The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.

Key facts

Study ID

NCT05468255

Run by

Old Dominion University

People needed

40

Starts

2022-07-25

Expected to finish

2025-04-01

Last updated by the study team

2024-04-10

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 55 years and older, 18-40 years old
• Healthy, physically active, performing at least 90 min/week of physical activity
• Free of physical limitations that may interfere with alterations in daily physical activity levels

You may not qualify if…

• Physician diagnosed HIV, hepatitis, or tuberculosis.
• Body weight change of greater than 5% within the previous 2 months
• Smoking within the previous 2 months.
• Taking medications that alter blood glucose levels

Where it is running

• Old Dominion University — Norfolk, Virginia, United States (enrolling)

Full record on ClinicalTrials.gov

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