Evaluation of Pharmacogenomics Testing to Precision Prescriptions in Periodontal Patients
Status unconfirmed · Phase 4
Conditions studied: Oral Surgeries
In brief
The different patients responses to medications vary from dose effectiveness to adverse drug reaction (ADRs). ADRs affect outpatient settings as it account for estimated 1 million emergency department visits and over 3.5 million physician office visits per year. This subsequently results in about 125,000 hospital admissions. Currently, genetic testing conclude recommendation of dose adjustment or drug stop. However, further step is needed toward individually tailored prescription plan. The purpose of this study is to determine if the efficacy of the genetic testing (Pharmacogenomics) combined with the dietary habits and medications history to design an individually tailored prescription plan. This individualized-prescriptions will be tested if to reduce adverse drug reaction and improve pain management in periodontal surgeries. Hence, the current study will recruit subjects planned for two periodontal surgeries and evaluate pain management during and after periodontal surgery as well as post-surgical complication with and without individually tailored prescription plan. In addition, a comparison will be performed on number of drugs added, stopped or had a dose adjustment.
Key facts
- Study ID
- NCT05467436
- Run by
- Augusta University
- People needed
- 35
- Starts
- 2020-01-01
- Expected to finish
- 2023-07-01
- Last updated by the study team
- 2022-07-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects at least 18 years of age
- All potential subjects must sign an informed consent prior to study enrollment
- Subjects willing to receive a standard full-mouth periodontal examination
- Subjects planned for 2 or more periodontal surgeries.
You may not qualify if…
- Subjects with medical conditions that contraindicate periodontal surgeries. These medical condition include: recent myocardial infarction and cerebrovascular accident, recent valve prosthesis surgery, immunosuppression, uncontrolled bleeding disorders, active treatment of malignancy as well as intravenous bisphosphonate use.
- Subjects with back and neck injuries that will not allow them to be in supine position.
Where it is running
- Augusta University-Dental College of Georgia — Augusta, Georgia, United States
Full record on ClinicalTrials.gov
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