Can Brief Exposure to Hyperoxia Improve Function After Chronic Spinal Cord Injury?

Recruiting now · Early Phase 1 · Has a placebo group

Conditions studied: Spinal Cord Injuries

In brief

This proof-of-principle study will determine if breathing an increased concentration of oxygen above the concentration in normal room air results in changes in the sensory and motor function in people with subacute or chronic, severe spinal cord injury (SCI).

Key facts

Study ID

NCT05467215

Run by

University of Alberta

People needed

25

Starts

2022-07-11

Expected to finish

2026-12-31

Last updated by the study team

2025-08-26

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Individuals with traumatic SCI with onset ≥3 months prior,
• Between 18 - 65 yr old,
• ASIA Impairment Scale at discharge classified as A, B or C,
• Injury level between C5 and T10,
• Able to give informed, written consent.

You may not qualify if…

• Frequent uncontrolled autonomic dysreflexia,
• Uncontrolled high blood pressure,
• Cardiac or cardiovascular disease,
• Cancer,
• Active urinary tract infection,
• Active pressure sores,
• Signs of deep vein thrombosis in the legs,
• Severe swelling of the feet and/or legs,
• Severe cognitive impairment,
• Pulmonary dysfunction such as chronic obstructive pulmonary disease or acute respiratory infection,
• Any condition which would be exacerbated by sitting or lying in one position for 2 hours, such as low back pain
• Pregnancy.

Where it is running

• University of Alberta, Clinical Sciences Bldg — Edmonton, Alberta, Canada (enrolling)

Full record on ClinicalTrials.gov

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