SV2A in Older Adults

Recruiting now · Phase 1/Phase 2

Conditions studied: Cannabis Use

In brief

The aim of the study is to examine the effect of cannabis use on brain synaptic density among older adults using \[11C\]UCB-J PET imaging.

Key facts

Study ID

NCT05465538

Run by

Yale University

People needed

24

Starts

2022-07-06

Expected to finish

2027-09-30

Last updated by the study team

2026-02-27

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Able to provide informed consent
• Male or female, aged ≥50 years
• No history of significant medical or neurological disease
• BMI ≤ 50
• If woman of childbearing potential, must agree to use an acceptable method of birth control, as determined by the principal investigator, for the duration of the study and up to one month after completion of PET scans

You may not qualify if…

• Women with a positive pregnancy test or women who are lactating
• Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits;
• History of a bleeding disorder or are currently taking anticoagulants
• Subjects who have donated blood within 8 weeks of the present study

Where it is running

• Conneticut Mental Health Center — New Haven, Connecticut, United States (enrolling)

Full record on ClinicalTrials.gov

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