Effect of Early Saline Lavage on Synovial Fluid Composition Following Intra Articular Ankle Fractures

Stopped early · Not applicable

Conditions studied: Intra-Articular Fractures

In brief

The purpose of this study is to examine the effect of early, percutaneous, intra-articular saline lavage on the undiluted synovial fluid microenvironment during the acute phase following intra-articular fracture of the human ankle. We hypothesize that early intervention with percutaneous joint lavage in the first 0-48 hours after injury will attenuate the production of pro-inflammatory cytokines, MMP's and cartilage breakdown products compared to non-lavaged control subjects at the time of surgical fixation.

Key facts

Study ID

NCT05465382

Run by

Duke University

People needed

41

Starts

2022-07-22

Expected to finish

2024-05-07

Last updated by the study team

2026-04-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult subjects (over 18 years of age)
• Must be treated at Duke University Hospital Emergency Department
• Intra-articular fracture of the ankle joint (any fracture of the fibula or tibia in which the fracture line(s) exit into the cartilage surface of the ankle joint)
• Subjects presenting between 0-48 hours from the time of injury

You may not qualify if…

• Age < 18 y.o.
• Open fracture
• Nonoperatively treated fractures
• Subjects presenting >48 hours from the time of injury

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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