Oliceridine in Patients With Acute Burn Injuries
Completed · Phase 4
Conditions studied: Acute Pain, Burns, Adverse Drug Event, Respiratory Depression, Nausea and Vomiting, Postoperative
In brief
Pain after acute burn injury is complex with much still not understood. The primary mechanism is believed to be nociceptive, but is interwoven with aspects of somatogenic, neuropathic, and psychogenic pathways. As such, opioid receptor agonists are an essential component for pain management after burn injury. The majority of wound care and dressing changes are completed in non-intubated patients and rates of respiratory depression concerning. Oliceridine is a biased, selective MOR agonist approved for treatment of acute pain. To date there is no literature of use in patients with burn injuries. While it should be effective, efficacy and the potential for reduced adverse events need to be quantified. Current practice and guidelines, plead for better analgesia for patients with burn injuries.
Key facts
- Study ID
- NCT05465226
- Run by
- University of Tennessee
- People needed
- 31
- Starts
- 2023-04-01
- Expected to finish
- 2023-10-24
- Last updated by the study team
- 2023-10-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 1) age ≥ 18 years old,
- 2) total body surface area (TBSA) burned < 20%
- 3) deep partial thickness or full thickness burns admitted for possible or definitive surgical needs,
- 4) moderate or severe pain related to acute burns (NRS ≥ 4 out of 10)
You may not qualify if…
- 1) Presence of inhalation injury,
- 2) Pregnant,
- 3) Incarcerated,
- 4) only initial admission,
- 5) known anaphylaxis to oliceridine or other opioids,
- 6) Patient or authorized representative unable or unwilling to consent,
- 7) known cocaine, methamphetamine, or opioid use history,
- 8) use of numeric rating scale (NRS) would be inaccurate or inappropriate
- 9) Significant hepatic dysfunction
Where it is running
- Regional One Health — Memphis, Tennessee, United States
Full record on ClinicalTrials.gov
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