CREST-2 Long-term Observational Extension Study

Running, not enrolling

Conditions studied: Stenoses, Carotid

In brief

The purpose of this Long-Term Observational Extension of Participants in the CREST-2 Randomized Clinical Trial (C2LOE - ClinicalTrials.gov Identifier: NCT02089217) study is to study is to assess post-procedural efficacy of carotid endarterectomy and carotid stenting.

Key facts

Study ID

NCT05465122

Run by

Mayo Clinic

People needed

2480

Starts

2022-07-05

Expected to finish

2027-08-31

Last updated by the study team

2026-05-28

Who can join

Age: 35 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Currently active or graduated participants in the CREST-2 randomized trial
• Able to provide written informed consent by self
• Fluent in English or Spanish

You may not qualify if…

• Unable to provide written informed consent
• Inability to follow study procedures

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• Mayo Clinic Pheonix — Phoenix, Arizona, United States
• Banner University Medical Center — Tucson, Arizona, United States
• Central Arkansas VA — Little Rock, Arkansas, United States
• Mission Cardiovascular Research Institute — Fremont, California, United States
• Kaiser Permanente Los Angeles — Los Angeles, California, United States
• USC/Keck Medical Center — Los Angeles, California, United States
• University of California Los Angeles — Los Angeles, California, United States
• Kaiser Permanente Divsion of Research — San Francisco, California, United States
• Kaiser Permanente San Francisco — San Francisco, California, United States
• St. Joseph's Medical Center — Stockton, California, United States
• Hartford Hospital — Hartford, Connecticut, United States
• Yale New Haven Hospital — New Haven, Connecticut, United States
• Morton Plant Mease Healthcare — Clearwater, Florida, United States
• University of Florida Health at Shands — Gainesville, Florida, United States
• Lyerly Neurosurgery/Baptist Health — Jacksonville, Florida, United States
• University of Florida Jacksonville — Jacksonville, Florida, United States
• Mayo Clinic Jacksonville — Jacksonville, Florida, United States
• Miami Cardiac and Vascular Institute — Miami, Florida, United States
• Cardiovascular Institute NW Florida — Panama City, Florida, United States
• University of Chicago Medical Center — Chicago, Illinois, United States
• Endeavor Health/NorthShore University — Evanston, Illinois, United States
• Prairie Heart/St. John's Hospital — Springfield, Illinois, United States
• Deaconess Heart Group — Newburgh, Indiana, United States
• VA Ann Arbor — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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