Impact of Intravenous Caffeine on Atrial Electrical Properties and Potential Arrythmia Induction

Starting soon · Not applicable · Has a placebo group

Conditions studied: Atrial Fibrillation

In brief

This "How caffeine Induces Atrial Tachyarrhythmias" trial will be a multi-center, randomized, double-blinded trial of intravenous caffeine versus placebo among patients undergoing pulmonary vein isolation procedures for Atrial Fibrillation(AF).

Key facts

Study ID

NCT05464940

Run by

Kansas City Heart Rhythm Research Foundation

People needed

100

Starts

2025-09-01

Expected to finish

2026-06-01

Last updated by the study team

2025-08-28

Who can join

Age: 21 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All adult patients from 21-90 years of age with new onset Paroxysmal Atrial Fibrillation presenting in sinus rhythm or AF of recent onset (the latter confirmed by sinus rhythm documented no more than 1 week prior) undergoing AF ablation will be included in the study.

You may not qualify if…

• Patients will be excluded if any of the following were identified:
• History of substance abuse or alcoholism.
• Left ventricular ejection fraction <50%.
• Liver dysfunction.
• Pregnancy.
• Inability to give informed consent.
• Amiodarone uses within 1 month prior to procedure.
• AAD use within 24 h prior to the procedure
• Severe intolerance to caffeine.

Where it is running

• Loma Linda University — Loma Linda, California, United States
• Menorah Medical Center — Overland Park, Kansas, United States
• Kansas City Heart Rhythm Institute — Overland Park, Kansas, United States
• Overland Park Regional Medical Center — Overland Park, Kansas, United States
• Centerpoint Medical Center Clinic — Independence, Missouri, United States
• Centerpoint Medical Center — Independence, Missouri, United States
• Research Medical Center Clinic — Kansas City, Missouri, United States
• Research Medical Center — Kansas City, Missouri, United States
• Texas Cardiac Arrythmia Institute — Austin, Texas, United States

Full record on ClinicalTrials.gov

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