Right Ventricle Lipid in Pulmonary Arterial Hypertension (PAH)
Recruiting now
Conditions studied: Idiopathic Pulmonary Arterial Hypertension, Heritable Pulmonary Arterial Hypertension, Pulmonary Arterial Hypertension Associated With Connective Tissue Disease
In brief
The investigators propose to study the relationship between right ventricle (RV) steatosis and RV function, exercise capacity, and outcomes in humans with pulmonary arterial hypertension (PAH) and to identify potential drivers of lipid accumulation.
Key facts
- Study ID
- NCT05462574
- Run by
- Vanderbilt University Medical Center
- People needed
- 75
- Starts
- 2023-01-17
- Expected to finish
- 2027-09-30
- Last updated by the study team
- 2026-05-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ≥ 18 years old
- Diagnosed with idiopathic, heritable, connective tissue disease-associated PAH, associated pulmonary arterial hypertension (PAH), or drug-or toxin-associated PAH according to World Health Organization (WHO) consensus recommendations.
- Stable PAH-specific medication regimen for three months prior to enrollment. Adjustments in IV prostacyclin for side effect management are allowed. Diuretic adjustments are permitted.
- WHO Functional Class I-III
- Ambulatory
- Able to have an MRI/MRS, perform a 6MWD test, and cardiopulmonary exercise test
You may not qualify if…
- Pregnancy
- Diagnosis of PAH etiology other than idiopathic, heritable, connective tissue disease - associated PAH or associated with drugs and toxins
- WHO Functional class IV heart failure
- Requirement for continuous oxygen
- Unable to have an MRI/MRS, perform a 6MWD test, or cardiopulmonary exercise test.
- Patients with implanted/embedded ferromagnetic material that would preclude cardiac MRI
Where it is running
- Vanderbilt University Medical Center — Nashville, Tennessee, United States (enrolling)
Full record on ClinicalTrials.gov
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