Neuromodulation of Memory in Aging
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Mild Cognitive Impairment, MCI
In brief
The proposed research will use closed-loop transcranial magnetic stimulation (TMS) based on individualized brain networks to establish parameters that can reliably control brain states. This will be tested in healthy aging and mild cognitive impairment (MCI) cohorts. The investigators will study network activation and neural oscillatory mechanisms underlying the network that regulates working memory and then target this network using closed-loop TMS to the Prefrontal Cortex. Investigators will measure the impact of TMS on working memory performance and task-based neural activity. The project will use brain stimulation and network modeling techniques to enhance working memory in healthy older adults and MCI and will demonstrate the value of closed-loop, network-guided TMS for future clinical applications.
Key facts
- Study ID
- NCT05460468
- Run by
- Duke University
- People needed
- 150
- Starts
- 2024-03-28
- Expected to finish
- 2027-06-30
- Last updated by the study team
- 2025-10-14
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- English Speaking
- Willing to provide consent
You may not qualify if…
- History of any Axis I DSM-V disorder, excluding major depressive disorder or generalized anxiety disorders
- Current history of substance abuse or dependence (excluding nicotine)
- Intracranial implants (e.g. aneurysms clips, shunts, stimulators, cochlear implants, or electrodes), cardiac pacemakers, or vagus Nerve stimulation device
- Increased risk of seizure for any reason, including prior diagnosis of epilepsy, seizure disorder, increased intracranial pressure, or history of significant head trauma with loss of consciousness for ≥ 5 minutes.
- Neurological disorder including, but not limited to: space occupying brain lesion; any history of seizures, history of cerebrovascular accident; fainting, cerebral aneurysm, Dementia, Hungtington chorea; Multiple Sclerosis.
- Current use of medications known to lower the seizure threshold and/or affect working memory
Where it is running
- Duke University Hospital — Durham, North Carolina, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.