Treatment Preventive for Pre-eclampsia by Acetylsalicylic Acid in Women Who Underwent Frozen Embryo Transfer

Recruiting now · Phase 3

Conditions studied: Embryo Transfer, Hypertension, Pregnancy Induced

In brief

Title: A prospective multicentric interventional randomized controlled trial to assess the effect of low dose acetylsalicylic acid as a preventive treatment of pre-eclampsia in pregnant women who underwent frozen embryo transfer

Key facts

Study ID

NCT05460416

Run by

Centre Hospitalier Universitaire de Liege

People needed

276

Starts

2022-10-25

Expected to finish

2026-06-30

Last updated by the study team

2025-02-18

Who can join

Age: 18 and older, up to 43. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Healthy women from [18 - 43] years-old, planned for a frozen embryo transfer, with natural and modified natural or HRT cycle
• Who have given their informed consent
• Who have a confirmed pregnancy at week 6 of amenorrhea.

You may not qualify if…

• Women presenting one risk factor for preeclampsia: multiple pregnancy, history of preeclampsia, BMI > 30, lupus syndrome, preexistent proteinuria, non-treated chronic high blood pressure (>140/90), antiphospholipid antibody syndrome, diabetes (fasting blood sugar >126mg/dl)
• Contraindication to acetylsalicylic acid (at risk of active hemorrhage (like hemophilia, …); at risk of or who have a gastro-duodenal ulcer; at risk or how have a terminal renal or hepatic in-sufficiency (only if acetylsalicylic acid is given at high dose)
• Already treated with acetylsalicylic acid
• Treatment with anticoagulants or non-steroid anti-inflammatory drugs

Where it is running

• Centre Hospitalier Universitaire de Liège site Citadelle — Liège, Belgium (enrolling)

Full record on ClinicalTrials.gov

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