Adjunctive Bright Light Therapy for Opioid Use Disorder

Completed · Not applicable · Has a placebo group

Conditions studied: Opioid Use Disorder, Sleep Disturbance

In brief

Investigators propose to conduct a pilot double-blind, parallel arm, randomized placebo-controlled trial evaluating the feasibility, acceptability, and preliminary efficacy of bright light therapy on reward system functioning among patients undergoing medication-assisted treatment for opioid use disorder.

Key facts

Study ID

NCT05459922

Run by

Arizona State University

People needed

23

Starts

2022-10-23

Expected to finish

2026-02-11

Last updated by the study team

2026-07-24

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age between 18 and 65
• ability to speak, write, and read in English
• past 2 weeks of insomnia as evidenced by Insomnia Severity Index (ISI) total score of ≥10
• enrolled in outpatient medication-assisted treatment for OUD (i.e., either methadone or buprenorphine treatment)
• been in medication-assisted treatment for at least 3 months
• at least one month of stable methadone or buprenorphine dose
• have a smartphone

You may not qualify if…

• lifetime history of bipolar disorder or mania
• current narcolepsy, sleep paralysis, or restless leg syndrome as assessed by medical history
• history of seizure disorders/epilepsy
• the STOP-Bang score for obstructive sleep apnea ≥ 5
• retinal pathology, history of eye surgery or taking photosensitizing medications (e.g., lithium, L-tryptophan)
• current regular use of melatonin
• have circumstances that would interfere with study participation (e.g., impending jail sentence)
• previous experience with bright light therapy
• working a night shift or traveling outside the Arizona time zone in the past month
• pregnant, trying to get pregnant, or breastfeeding
• currently wearing prescription glasses with blue-light protection

Where it is running

• Arizona State University — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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