Renal Considerations in the Heat Stress Recommendations (Aim2)

Completed · Not applicable

Conditions studied: Hot Weather; Adverse Effect, Kidney Dysfunction, Kidney Injury, Hyperthermia, Dehydration

In brief

An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is largely unknown, but may be related to kidney dysfunction caused by increases in body temperature and dehydration that elicit oxidative stress and inflammation in the renal tubules. The purpose of this study is to determine whether hydration status modifies the development of renal oxidative stress and inflammation.

Key facts

Study ID

NCT05458843

Run by

Indiana University

People needed

18

Starts

2022-08-01

Expected to finish

2023-05-22

Last updated by the study team

2023-11-08

Who can join

Age: 18 and older, up to 44. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women
• 18-44 y old
• Body mass index ≤35.0 kg/m2
• Self-reported to be healthy

You may not qualify if…

• Not within defined age range
• Estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2
• Body mass index >35.0 kg/m2
• Current or history of any renal disease, heart disease, stroke, immune or autoimmune disease, and/or gastrointestinal disease/surgery
• Hypertension during screening (systolic blood pressure >139 or diastolic blood pressure >89)
• Using medications that blunt the physiological response to exercise (e.g., beta blockers)
• Prescription medication with a known side effect of impaired temperature regulation or fluid balance (e.g., diuretics)
• Positive pregnancy test at any time during the study or breast feeding
• Current tobacco or electronic cigarette use or consistent use within the last 2 years
• Answered "Yes" to any question on Page 1 of the PAR-Q+.

Where it is running

• School of Public Health — Bloomington, Indiana, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.