Postpartum Vaginal Estrogen for Breastfeeding Patients
Recruiting now · Phase 4
Conditions studied: Breastfeeding, Postpartum Sexual Dysfunction, Vaginal Atrophy
In brief
Sexual dysfunction is very common in the postpartum period and is more common in people who breastfeed or pump. This research study was designed to help determine whether postpartum patients who use vaginal estrogen cream while breastfeeding have improved sexual function compared to postpartum patients who do not.
Key facts
- Study ID
- NCT05457972
- Run by
- University Hospitals Cleveland Medical Center
- People needed
- 100
- Starts
- 2025-02-22
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-07-23
Who can join
Age: 18 and older, up to 50. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 or older
- Sexually active
- Singleton, term (37 weeks 0 days) birth
- Planning to breastfeed or pump during the study period
- History of successful breastfeeding or pumping after a prior pregnancy
- Between 6 weeks and 6 months postpartum (patients may be recruited at any time during the postpartum period, but the study period will not start until 6 weeks postpartum)
- Ability to consent in English
- Not meeting any exclusion criteria
You may not qualify if…
- Preterm delivery
- Perinatal mortality
- History of difficulty breastfeeding
- 3rd or 4th degree perineal laceration
- Any contraindications to estrogen, including, but not limited to, breast cancer or a history of breast cancer, estrogen-dependent neoplasia, active deep vein thrombosis (DVT)/pulmonary embolism (PE) or a history of these conditions, active arterial thromboembolic disease (for example, stroke and MI) or a history of these conditions, known anaphylactic reaction, angioedema, or hypersensitivity to estrogen, hepatic impairment or disease, protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders.
Where it is running
- University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States (enrolling)
Full record on ClinicalTrials.gov
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